• Introduction

    A multidisciplinary approach is currently preferred in diagnosis and treatment decision-making in pituitary adenoma patients. In the multidisciplinary neuro-endocrine meetings of the University Medical Center Groningen, the clinical benefits as opposed to potential side effects of radiation therapy, as reported by other centres, were frequently debated, resulting in suboptimal consistency in our approach to this patient category. In order to increase our understanding of the clinical consequences of (post-operative) radiation therapy as compared to no radiation therapy, it was decided to evaluate the outcome of this treatment among pituitary adenoma patients treated in our institution during the past decades. The single-centre cohort studies described in this thesis are aimed to improve evidence-based decision-making in pituitary adenoma patients.

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