• Hormonal substitution free survival

    Preoperatively, no significant differences in anterior pituitary hormonal substitution were found between Group 1 and 2 (Table 1). Directly after first surgery, again, no differences were found regarding thyroid hormone-, glucocorticoid-, or sex hormone substitution between Group 1 and 2 (Table 1). At the end of follow-up, the need for hormonal substitution was also not different between the groups (Table 1). The number of hormone deficiencies per patient at diagnosis, directly after first surgery and at the end of follow-up was comparable between Group 1 and 2 (Table 1). As shown in Figure 2 – 4, there were no differences in hormone substitution free survival with respect to thyroid hormone, glucocorticoids, and sex hormones between the groups during the study period after first surgery.
    Before surgery one patient in Group 1 and none in Group 2 had antidiuretic hormone deficiency. Postoperatively, an additional 6 patients in Group 1 and 2 patients in Group 2 required permanent vasopressin treatment. These numbers did not change until end of follow-up in either group (p = 0.97). Furthermore, the type of operation was not associated with vasopressin-substitution (p = 0.99).

    Figure 2 (click to view)

    Figure 2 (click to view)

    Figure 3 (click to view)

    Figure 3 (click to view)

    Figure 4 (click to view)

    Figure 4 (click to view)

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