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Chapter 1
Introduction
Pituitary Anatomy
Pituitary adenomas
Incidence en prevalence
Clinical symptoms
Mortality
Treatment modalities
Active surveillance
Medication
Surgery
Radiation therapy
Radiation therapy treatment schedules
Non-functioning pituitary adenoma
Prolactinoma
GH-secreting pituitary adenoma
ACTH-secreting pituitary adenoma
Mortality and radiation therapy
Side-effects of radiation therapy
Acute side-effects
Late side-effects
Hypopituitarism
Pituitary function and pregnancy
Cerebrovascular disease (CVD)
Tumour induction
Tumour induction inside the brain
Tumour induction outside the brain
Brain necrosis
Radiation Optic Neuropathy (RON)
Cognitive function
Quality of Life
Aims of this thesis
Reference List
Chapter 2
Introduction
Methods and materials
Patients
Radiotherapy
Progression and hormonal evaluation
Statistical analysis
Results
Local Control Rate
Hormonal substitution free survival
Cerebrovascular disease
Epilepsy
Tumor induction
Overall survival and life expectancy
Discussion
References
Chapter 3
Abstract
Introduction
Methods and Materials
Patients
Questionnaires
Laboratory assays
Statistical analysis
Results
Discussion
References
Letter to the editor
To the Editor
References
To the Editor
References
Chapter 4
Abstract
Introduction
Materials and Methods
Results and Discussion
Case 1
Case 2
References
Chapter 5
Introduction
Literature search and data analysis
Incidence of RON
Severity of visual loss and latency of RON occurrence
RON in relation to radiation treatment characteristics
Other risk factors for RON development
Pathogenesis and treatment
Conclusions
References
Chapter 6
Abstract
Introduction
Methods
Results
Discussion
References
Chapter 7
Abstract
Introduction
Patients and methods
PET acquisition and imaging analysis
TYR-production
Blood sampling
Camera
MRI acquisition and imaging analysis
Statistical analysis
Results
Discussion
Reference List
chapter 8
Abstract
Introduction
Materials and Methods
Bellinzona technique
Tetrahedron technique
Analysis of portal images of oblique radiation beams
Results
Validation of the method
Bellinzona technique
Tetrahedron technique
Discussion
Conclusions
Appendix A
References
Chapter 9
General discussion
References
Dankwoord
Fons van den Bergh
Proefschrift
Publicationlist
Samenvatting
Hoofdstuk 1
Hoofdstuk 2
Hoofdstuk 3
Hoofdstuk 4
Hoofdstuk 5
Hoofdstuk 6
Hoofdstuk 7
Hoofdstuk 8
Hoofdstuk 9
Summary
Chapter 1
Chapter 2
Chapter 3
Chapter 4
Chapter 5
Chapter 6
Chapter 7
Chapter 8
Chapter 9
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